PABOX

Method for synthesising modified glycerophospholipid probes and their applications

Background

In the pursuit of increasingly precise and efficient biotechnological tools, the controlled functionalisation of cell membranes has emerged as a significant challenge. Glycerophospholipids, essential components of biological membranes, play a central role in numerous physiological processes. Despite their importance, achieving their site-specific and controlled chemical modification has remained a complex task. This limitation has significantly constrained the development of advanced applications in the fields of biology, diagnostics, and therapeutics.

Technology overview
We have developed an innovative process enabling the synthesis of synthetic glycerophospholipids incorporating at least one reactive chemical group. These novel lipid derivatives serve as versatile scaffolds that can be readily functionalised with a wide range of molecular entities. This breakthrough facilitates the precise anchoring and conjugation of various biomolecules for diverse applications.

Stage of Development
The technology has been successfully validated in a laboratory setting with proof-of-concept data demonstrating both efficiency and biocompatibility.

Benefits

• High Biocompatibility: Offers a flexible and biologically respectful solution, with compounds designed to maintain cellular integrity and compatibility across multiple environments.
  
• Facilitated Bioconjugation: Enables stable and selective attachment of biomolecules, imaging probes, or therapeutic agents, supporting the development of bespoke tools tailored to specific research or industrial purposes.
• Targeted Delivery and Vectorisation: Enhances the precision of biomarker or drug distribution by exploiting the natural integration of these lipids into biological membranes or their capacity to form functional vesicular systems.

Applications

• Research in membrane biology and lipid–protein interactions
  
• Functional membrane modelling and cell labelling
• Custom vesicle formation for in vitro or in vivo applications
  
• Diagnostic imaging and biosensors
• Targeted drug delivery systems
  

Opportunity
These lipid derivatives present a transformative opportunity for entities operating in biomedical research, pharmaceutical development, and diagnostic innovation. It opens new avenues for developing advanced therapies, targeted delivery systems, and next-generation analytical tools.

Seeking

Licensing, Assignement

IP

Patented (priority year 2022)