BuCHE
Bioscavengers against Organophosphorus Neurotoxic Agents
Bioscavengers against Organophosphorus Neurotoxic Agents
Background
In light of escalating chemical threats and the associated risks of intoxication by neurotoxic agents, there is a pressing need for effective countermeasures. Exposure to organophosphorus neurotoxic agents (OPNAs), including chemical warfare agents such as sarin and VX, as well as certain pesticides, poses significant health risks to both civilian and military populations.
Technology overview
This patented technology introduces a novel class of chemical compounds specifically engineered to reactivate butyrylcholinesterase (BChE) that has been inhibited by OPNAs. Unlike conventional pyridinium oximes, these compounds demonstrate targeted reactivation of BChE and can be administered either independently or in conjunction with BChE.
Stage of Development
Benefits
- Targeted reactivation: Specific reactivation of BChE, surpassing the performance of standard treatments.
- Versatility: Effective as both an antidote and a detoxification agent.
- Rapid response: Enables swift intervention following OPNA exposure.
- Dual application: Suitable for both civilian and military use.
Applications
- Medical countermeasures: Emergency treatment for OPNA intoxication.
- Preventative measures: Prophylactic use in high-risk environments.
This technology addresses a critical gap in the protection against chemical threats, offering a robust and innovative solution for the rapid and effective reactivation of BChE. Its versatility and efficacy position it as a valuable asset for public health, defence and environmental safety sectors.
Seeking
Development partner, Licensing
IP
Patent application submitted (priority year 2020)